Update 2024-12-17: All EVcouplings servers and resources will be offline from Jan 3rd to Jan 10th 2025 due to a data center relocation. Please note it will not be possible to submit new or view finished compute jobs during that time window, and any jobs still running on Jan 3rd will be terminated.
Webservers and interactive resources
Evolutionary couplings can be used to predict many interesting aspects about protein and RNA molecules from sequence alone.
EVcouplings server
Compute evolutionary couplings from sequence alignments and predict 3D structure for your protein of interest.
SARS-CoV-2
3D structure and mutation effect prediction for SARS-CoV-2 proteins and RNAs.
Precomputed results
Precomputed evolutionary couplings and 3D models for thousands of experimentally unsolved proteins.
EVcomplex server
Predict interacting residues in protein complexes from sequence covariation for your complex of interest.
EVmutation
Context-dependent mutation landscapes predicted for thousands of human proteins.
Protein plasticity
Coevolutionary prediction of conformations of disordered regions in the human proteome.
RNA structure
3D structure of RNA molecules and protein-RNA interactions predicted from nucleotide sequence covariation.
E. coli complexes
Precomputed predictions for Escherichia coli proteome, including the full membrane protein interactome.