Update 2024-08-26: The main server (v2.evcouplings.org) is back online!
Update 2024-09-28: The legacy server (v1.evcouplings.org) is also back (but will not be returning results from the 'compare' stage anymore). For monomer runs, we strongly encourage users to only use v2 going forward.
Please reach out to support@evcouplings.org if you encounter any further issues or have any questions.
Webservers and interactive resources
Evolutionary couplings can be used to predict many interesting aspects about protein and RNA molecules from sequence alone.
EVcouplings server
Compute evolutionary couplings from sequence alignments and predict 3D structure for your protein of interest.
SARS-CoV-2
3D structure and mutation effect prediction for SARS-CoV-2 proteins and RNAs.
Precomputed results
Precomputed evolutionary couplings and 3D models for thousands of experimentally unsolved proteins.
EVcomplex server
Predict interacting residues in protein complexes from sequence covariation for your complex of interest.
EVmutation
Context-dependent mutation landscapes predicted for thousands of human proteins.
Protein plasticity
Coevolutionary prediction of conformations of disordered regions in the human proteome.
RNA structure
3D structure of RNA molecules and protein-RNA interactions predicted from nucleotide sequence covariation.
E. coli complexes
Precomputed predictions for Escherichia coli proteome, including the full membrane protein interactome.