Protein and RNA structure, function and fitness predicted from evolutionary sequence covariationPredict your protein
Dear users, due to ongoing technical issues the original EVcouplings server, EVcomplex submissions and precomputed results are currently not available. We are working on a fix and apologize for the inconvenience.
In the meantime, please use our new EVcouplings server with enhanced features (example results can be found here).
Evolutionary couplings can be used to predict many interesting aspects about protein and RNA molecules from sequence alone.
Compute evolutionary couplings from sequence alignments and predict 3D structure for your protein of interest.
3D structure and mutation effect prediction for SARS-CoV-2 proteins and RNAs.
Precomputed evolutionary couplings and 3D models for thousands of experimentally unsolved proteins.
Predict interacting residues in protein complexes from sequence covariation for your complex of interest.
Context-dependent mutation landscapes predicted for thousands of human proteins.
Coevolutionary prediction of conformations of disordered regions in the human proteome.
3D structure of RNA molecules and protein-RNA interactions predicted from nucleotide sequence covariation.
Precomputed predictions for Escherichia coli proteome, including the full membrane protein interactome.
Large file downloads for our papers related to evolutionary couplings.
Data for in-vitro experimental evolution to compute evolutionary couplings.
We provide access to our evolutionary couplings methods as open source software. For details about each tool, please refer to the individual repositories.
Application and Python package providing the complete EVcouplings workflow from alignment to structure.
Software to infer undirected pairwise graphical models from multiple sequence alignments.
Python module to predict mutation effects from undirected graphical models of sequences.
Tool to interactively visualize the parameters of undirected graphical models of protein families.